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Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2

Abstract:

Hypoxia is central to both ischaemic and neoplastic diseases. However, the non-coding transcriptional response to hypoxia is largely uncharacterized. We undertook integrated genomic analyses of both non-coding and coding transcripts using massively parallel sequencing and interfaced this data with pan-genomic analyses of hypoxia-inducible factor (HIF) and RNApol2 binding in hypoxic cells. These analyses revealed that all classes of RNA are profoundly regulated by hypoxia and implicated HIF as...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/embr.201337642

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0003-0401-6619
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
ORCID:
0000-0002-3587-8839
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0003-0756-5752
Expand authors...
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Reports Journal website
Volume:
15
Issue:
1
Pages:
70-76
Place of publication:
England
Publication date:
2013-12-22
Acceptance date:
2013-10-22
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Pmid:
24363272
Language:
English
Keywords:
Pubs id:
444141
Local pid:
pubs:444141
Deposit date:
2020-06-03

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