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Thesis

Histone lysine and DNA methylation: dynamic marks in the chromatin

Abstract:

Ten-eleven translocation (TET) enzymes are epigenetic enzymes that are responsible for the iterative oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine (5caC) on genomic DNA using a catalytic 2-oxoglutarate (2OG) dependent oxygenase domain. These epigenetic marks are associated with transcriptional activation and silencing depending on the modification and context. Furthermore, 5fC and 5caC participate in active demethylatio...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0002-7396-4295

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Research group:
Kawamura group
Role:
Supervisor
ORCID:
0000-0003-1169-5082
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Supervisor
More from this funder
Programme:
Dorothy Hodgkin Fellowship
Funding agency for:
Kawamura, A
Grant:
DH120028
More from this funder
Programme:
CRUK Oxford Centre
Funding agency for:
Kawamura, A
Grant:
C5255/A18085
More from this funder
Funding agency for:
Kawamura, A
Grant:
679479
More from this funder
Funding agency for:
Kawamura, A
Grant:
C8717/A18245
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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