Translating tolerogenic therapies to the clinic - where do we stand?

Journal article

Abstract:: Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation. A number of experimental techniques exploiting central and peripheral tolerance mechanisms have demonstrated success, leading to the first early phase clinical trials for tolerance induction. The first major strategy centers on the facilitation of donor-cell mixed chimerism in the transplant recipient with the use of bone marrow or hematopo...
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Institution:

University of Oxford

Division:

MSD

Department:

Surgical Sciences

Role:

Author

Institution:

University of Oxford

Division:

MSD

Department:

Surgical Sciences

Role:

Author

Language:: English
Keywords:: transplantation

clinical trials

regulatory T cell

chimerism

cellular therapy

tolerance

immune regulation
Pubs id:: pubs:349850
UUID:: uuid:c24117f8-3484-4b9d-9a3c-e40f45e6794c
Local pid:: pubs:349850
Source identifiers:: 349850
Deposit date:: 2013-11-17

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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