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Thesis

Mechanisms underlying statin-induced modulation of ryanodine receptors

Abstract:

Statins, a class of HMG-CoA reductase inhibitors, are amongst the most widely prescribed drugs for the treatment of elevated cholesterol. Despite their success, their use is associated with debilitating muscle side effects such a myopathy, myalgia and in the most serious cases, rhabdomyolysis. These effects have limited the ability of many patients to tolerate statin treatment. There is mounting evidence suggesting that statins cause a dysfunction of cellular Ca2+-release in skeletal muscl...

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Division:
MPLS
Department:
Chemistry
Oxford college:
Trinity College
Role:
Author

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Supervisor
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Supervisor
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Programme:
DPhil Cardiovascular Medicinal Chemistry Programme
Grant:
RE/08/004
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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