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Journal article

Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications

Abstract:

Aims Myocardial fibrosis as detected by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is a powerful prognostic marker in hypertrophic cardiomyopathy (HCM) and may be progressive. The precise mechanisms underlying fibrosis progression are unclear. We sought to assess the extent of LGE progression in HCM and explore potential causal mechanisms and clinical implications.

Methods and results Seventy-two HCM patients had two CMR...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ehjci/jey135

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Ohuma, EO
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Funding agency for:
Rodgers, C
Grant:
Sir Henry Dale Fellowship: 098436/Z/12/B
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Funding agency for:
Mahmod, M
Grant:
Oxford Biomedical Research Centre
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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal: Cardiovascular Imaging Journal website
Volume:
20
Issue:
2
Pages:
157–167
Publication date:
2018-10-24
Acceptance date:
2018-09-05
DOI:
EISSN:
2047-2412
ISSN:
2047-2404
Keywords:
Pubs id:
pubs:935936
UUID:
uuid:c26a77fc-9c75-4d9b-8c4d-0ce1eb3c5696
Local pid:
pubs:935936
Deposit date:
2018-10-31

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