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Thesis

iASPP in the balance between tolerance and autoimmunity

Abstract:

Maintenance of immunological homeostasis between tolerance and autoimmunity is essential for the prevention of human diseases ranging from autoimmune disease to cancer. Adaptive immune responses require both antigenicity and adjuvanticity, and cell death can critically influence immunological homeostasis by modulating the adjuvanticity it elicits. Accumulating evidence suggests that in addition to inducing apoptosis, p53 mitigates phagocytosis-induced adjuvanticity thereby promoting tole...

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Division:
MSD
Role:
Author

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Role:
Supervisor
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Funding agency for:
Akama-Garren, E
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Keywords:
Subjects:
UUID:
uuid:c2742be8-dfd1-4012-84eb-da0ef60d76ab
Deposit date:
2018-05-19

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