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Not all T cell synapses are built the same way

Abstract:

T cells comprise functionally diverse subtypes. Although activated via a conserved scheme of antigen recognition by their T cell receptor, they elicit heterogeneous activation and effector responses. Such functional diversity has been appreciated in gene expression studies, functional assays, and disease models. Yet, our understanding of the principles underlying T cell subtype-specific activation and antigen recognition in the immunological synapse remains limited. This is primarily due to d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.it.2019.09.009

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Oxford college:
Balliol College
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Trends in Immunology Journal website
Publication date:
2019-10-20
Acceptance date:
2019-09-20
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
Pmid:
31645298
Source identifiers:
1069544
Language:
English
Keywords:
Pubs id:
pubs:1069544
UUID:
uuid:c29e2406-b55e-4684-ba93-137dc06c4e56
Local pid:
pubs:1069544
Deposit date:
2019-11-13

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