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Membrane mechanical properties regulate the effect of strain on spontaneous electrophysiology in human iPSC-derived neurons

Abstract:

Peripheral nerves contain neuron fibres vital for movement and sensation and are subject to continuous elongation and compression during everyday movement. At supraphysiological strains conduction blocks occur, resulting in permanent or temporary loss of function. The mechanisms underpinning these alterations in electrophysiological activity remain unclear, however there is evidence that both ion channels and network synapses may be affected through cell membrane transmitted strain. The aim o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuroscience.2019.02.014

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Balliol College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-0701-5040
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0001-7613-6041
Publisher:
Elsevier Publisher's website
Journal:
Neuroscience Journal website
Volume:
404
Pages:
165-174
Publication date:
2019-02-26
Acceptance date:
2019-02-11
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
Pmid:
30817953
Source identifiers:
978308
Language:
English
Keywords:
Pubs id:
pubs:978308
UUID:
uuid:c2a7a9f7-6fa5-456f-84f3-a6a2534d8576
Local pid:
pubs:978308
Deposit date:
2019-03-05

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