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Journal article

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice

Abstract:

Vascular dysfunction in small resistance arteries is observed during chronic elevations in blood glucose. Hyperglycaemia-associated effects on endothelium-dependent vasodilation have been well characterized, but effects on conducted vasodilation in the resistance vasculature are not known. Small mesenteric arteries were isolated from healthy and diabetic db/db mice, which were used as a model of chronic hyperglycaemia. Endothelium-dependent vasodilation via the Gq/11-coupled proteinase activa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vph.2018.01.002

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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Magdalen College
Role:
Author
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Funding agency for:
Lemmey, H
Grant:
PhD Studentship
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Grant:
National Priorities Research Program grant 4-9103-244
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vascular Pharmacology Journal website
Volume:
103-105
Pages:
29-35
Publication date:
2018-01-12
Acceptance date:
2018-01-10
DOI:
ISSN:
1537-1891
Source identifiers:
819414
Keywords:
Pubs id:
pubs:819414
UUID:
uuid:c2d82259-daf8-4615-aa7d-19c459d56cae
Local pid:
pubs:819414
Deposit date:
2018-01-14

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