A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.

Journal article

Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of potentially toxic immunosuppressive therapy. Gene expression-based biomarkers facilitating such tailoring of chemotherapy in cancer, but not autoimmunity, have been identified and translated into clinical practice. We show that transcriptional profiling of purified CD8(+) T cells, which avoids the confounding influences of unseparated ...

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Authors: McKinney, E; Lyons, P; Carr, E; Hollis, J; Jayne, DR

• Publication status: Published
• Journal: Nature medicine
• Volume: 16
• Issue: 5
• Pages: 586-591
• Publication date: 2010-05-01
• DOI: 10.1038/nm.2130
• EISSN: 1546-170X
• ISSN: 1078-8956
• Language: English
• Keywords: Interleukin-7; Signal Transduction; Prognosis; Autoimmunity; Antibodies, Antineutrophil Cytoplasmic; Lupus Erythematosus, Systemic; Dose-Response Relationship, Drug; Autoimmune Diseases; Inflammation; Gene Expression; CD8-Positive T-Lymphocytes; Receptors, Antigen, T-Cell; T-Lymphocytes; Humans; Vasculitis; Immunosuppressive Agents; Cohort Studies