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Journal article

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.

Abstract:

Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of potentially toxic immunosuppressive therapy. Gene expression-based biomarkers facilitating such tailoring of chemotherapy in cancer, but not autoimmunity, have been identified and translated into clinical practice. We show that transcriptional profiling of purified CD8(+) T cells, which avoids the confounding influences of unseparated ...

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Publication status:
Published

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Publisher copy:
10.1038/nm.2130

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Journal:
Nature medicine
Volume:
16
Issue:
5
Pages:
586-591
Publication date:
2010-05-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Source identifiers:
119911

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