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Journal article

Disruption of coronin 1 signaling in T cells promotes allograft tolerance while maintaining anti-pathogen immunity

Abstract:

The ability of the immune system to discriminate self from non-self is essential for eradicating microbial pathogens but is also responsible for allograft rejection. Whether it is possible to selectively suppress alloresponses while maintaining anti-pathogen immunity remains unknown. We found that mice deficient in coronin 1, a regulator of naive T cell homeostasis, fully retained allografts while maintaining T cell-specific responses against microbial pathogens. Mechanistically, coronin 1-de...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.immuni.2018.12.011

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Publisher:
Elsevier Publisher's website
Journal:
Immunity Journal website
Volume:
50
Issue:
1
Pages:
152-165.e8
Publication date:
2019-01-02
Acceptance date:
2018-12-10
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Pmid:
30611611
Source identifiers:
963613
Language:
English
Pubs id:
pubs:963613
UUID:
uuid:c388d831-2faa-4d11-925f-e6371b454d2b
Local pid:
pubs:963613
Deposit date:
2019-02-10

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