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Comparison of ion channel gene expression in the sinus node of the human, rabbit, rat and mouse

Abstract:

Small animal species (e.g. mouse) have a faster heart rate than large animal species (e.g. human). We have looked for the reason from the functional level to the gene level in the human, rabbit, rat and mouse using a 'metaanalysis' approach. For example, review of the literature shows that, in isolated sinus node cells, the spontaneous rate is 4.6× faster and the action potential is 2.4 × shorter in mouse than in human. Although data on ionic currents are limited, data suggests that the densi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Publisher:
Institute of Electrical and Electronics Engineers Publisher's website
Journal:
Computing in Cardiology 2016 Journal website
Volume:
43
Pages:
1105-1108
Host title:
Computing in Cardiology 2016
Publication date:
2017-03-01
EISSN:
2325-887X
ISSN:
2325-8861
Source identifiers:
689222
ISBN:
9781509008964
Pubs id:
pubs:689222
UUID:
uuid:c3b64195-d649-4533-9196-f51c48266343
Local pid:
pubs:689222
Deposit date:
2017-06-12

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