Conference item
Comparison of ion channel gene expression in the sinus node of the human, rabbit, rat and mouse
- Abstract:
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Small animal species (e.g. mouse) have a faster heart rate than large animal species (e.g. human). We have looked for the reason from the functional level to the gene level in the human, rabbit, rat and mouse using a 'metaanalysis' approach. For example, review of the literature shows that, in isolated sinus node cells, the spontaneous rate is 4.6× faster and the action potential is 2.4 × shorter in mouse than in human. Although data on ionic currents are limited, data suggests that the densi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 456.9KB)
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Bibliographic Details
- Publisher:
- Institute of Electrical and Electronics Engineers Publisher's website
- Journal:
- Computing in Cardiology 2016 Journal website
- Volume:
- 43
- Pages:
- 1105-1108
- Host title:
- Computing in Cardiology 2016
- Publication date:
- 2017-03-01
- EISSN:
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2325-887X
- ISSN:
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2325-8861
- Source identifiers:
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689222
- ISBN:
- 9781509008964
Item Description
- Pubs id:
-
pubs:689222
- UUID:
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uuid:c3b64195-d649-4533-9196-f51c48266343
- Local pid:
- pubs:689222
- Deposit date:
- 2017-06-12
Terms of use
- Copyright holder:
- Computing in Cardiology
- Copyright date:
- 2017
- Notes:
- © Computing in Cardiology. All rights reserved.
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