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Thesis

Identification of novel players implicated in replication-dependent and independent DNA interstrand crosslink (ICL) repair

Abstract:

The integrity of the genome is constantly under threat from within and without. Cells rely on the evolutionary conserved DNA damage response (DDR) mechanism to orchestrate the repair of DNA lesions and thus prevent the accumulation of mutations. One of the most deleterious types of DNA lesions, interstrand crosslink (ICL), occurs when a crosslinking agent forms covalent bonds with both strands of the double helix and tethers them together. The most well-studied among ICL repair pathways is...

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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0002-2988-3009
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Programme:
Cyril and Phillis Long Scholarship
Funding agency for:
Yaprianto, K
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Programme:
Clarendon Scholarship
Funding agency for:
Yaprianto, K
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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