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Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia

Abstract:

The current understanding of the role of the cell membrane is in a state of flux. Recent experiments show that conventional models, considering only electrophysiological properties of a passive membrane, are incomplete. The neuronal membrane is an active structure with mechanical properties that modulate electrophysiology. Protein transport, lipid bilayer phase, membrane pressure and stiffness can all influence membrane capacitance and action potential propagation. A mounting body of evidence...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.actbio.2019.07.041

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0001-5026-8038
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Acta Biomaterialia Journal website
Volume:
97
Pages:
116-140
Publication date:
2019-07-26
Acceptance date:
2019-07-23
DOI:
ISSN:
1742-7061
Source identifiers:
1035080
Keywords:
Pubs id:
pubs:1035080
UUID:
uuid:c49fa42e-2f19-4191-aefc-0fdd8ed34406
Local pid:
pubs:1035080
Deposit date:
2019-07-25

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