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Thesis

Structural studies of the PIR and RIFIN families from malaria-infected erythrocytes

Abstract:

Malaria, caused by the Plasmodium parasite, is responsible for the deaths of close to half a million people a year. During the course of infection, the parasite invades and remodels the host red blood cell, often requiring the export of a number of proteins to the erythrocyte surface. These include the RIFIN family of Plasmodium falciparum, which have been shown to directly modulate the host immune response through interactions with inhibitory immune receptors such as LILRB1 and LAIR1. Add...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Research group:
Higgins
Oxford college:
Merton College
Role:
Author
ORCID:
https://orcid.org/0000-0003-1579-8484

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Research group:
Higgins
Oxford college:
Merton College
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Supervisor
More from this funder
Programme:
Peter J. Braam Global Wellbeing Graduate Scholarship
Funding agency for:
Harrison, TE
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-02-05

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