Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism
BACKGROUND. Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, with increased rates of insulin resistance, type 2 diabetes, and osteoporosis, which cannot be easily explained by aldosterone excess.
METHODS. We performed mass spectrometry–based analysis of a 24-hour urine steroid ... Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 983.7KB)
- Publisher copy:
- Copyright holder:
- Arlt et al
- Copyright date:
- © 2017 Arlt et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record