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Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

Abstract:
BACKGROUND. Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, with increased rates of insulin resistance, type 2 diabetes, and osteoporosis, which cannot be easily explained by aldosterone excess.

METHODS. We performed mass spectrometry–based analysis of a 24-hour urine steroid ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.93136

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Role:
Author
ORCID:
0000-0001-7727-4497
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI insight Journal website
Volume:
2
Issue:
8
Pages:
e93136
Publication date:
2017-04-20
Acceptance date:
2017-03-14
DOI:
EISSN:
2379-3708
Pmid:
28422753
Source identifiers:
963084
Language:
English
Keywords:
Pubs id:
pubs:963084
UUID:
uuid:c5e245b5-e297-4126-ad3e-6003c482df2a
Local pid:
pubs:963084
Deposit date:
2019-01-22

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