Journal article
Targeting protein–protein interactions in the HIF system
- Abstract:
-
Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the hypoxia‐inducible factor (HIF). HIF upregulates multiple genes, the products of which work to ameliorate the effects of limited oxygen at cellular and systemic levels. Hypoxia sensing by the HIF system involves hydroxylase‐catalysed post‐translational modifications of the HIF α‐subunits, which 1) signal for degradation of HIF‐α and 2) limit binding of HIF to trans...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- ChemMedChem Journal website
- Volume:
- 11
- Issue:
- 8
- Pages:
- 773-786
- Publication date:
- 2016-03-21
- DOI:
- EISSN:
-
1860-7187
- ISSN:
-
1860-7179
- Pmid:
-
26997519
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:611926
- UUID:
-
uuid:c665603d-e1c0-4cd6-98ee-6b6534064c8d
- Local pid:
- pubs:611926
- Source identifiers:
-
611926
- Deposit date:
- 2017-03-07
Terms of use
- Copyright holder:
- Wilkins et al.
- Copyright date:
- 2016
- Rights statement:
- © The Authors 2016. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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