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Journal article

Targeting protein–protein interactions in the HIF system

Abstract:

Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the hypoxia‐inducible factor (HIF). HIF upregulates multiple genes, the products of which work to ameliorate the effects of limited oxygen at cellular and systemic levels. Hypoxia sensing by the HIF system involves hydroxylase‐catalysed post‐translational modifications of the HIF α‐subunits, which 1) signal for degradation of HIF‐α and 2) limit binding of HIF to trans...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cmdc.201600012

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Oxford college:
Linacre College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Wiley Publisher's website
Journal:
ChemMedChem Journal website
Volume:
11
Issue:
8
Pages:
773-786
Publication date:
2016-03-21
DOI:
EISSN:
1860-7187
ISSN:
1860-7179
Pmid:
26997519
Source identifiers:
611926
Language:
English
Keywords:
Pubs id:
pubs:611926
UUID:
uuid:c665603d-e1c0-4cd6-98ee-6b6534064c8d
Local pid:
pubs:611926
Deposit date:
2017-03-07

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