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Journal article

Regioisomeric family of novel fluorescent substrates for SHIP2

Abstract:

SHIP2 (SH2-domain containing inositol 5-phosphatase type 2) is a canonical 5-phosphatase, which, through its catalytic action on PtdInsP3, regulates the PI3K/Akt pathway and metabolic action of insulin. It is a drug target, but there is limited evidence of inhibition of SHIP2 by small molecules in the literature. With the goal to investigate inhibition, we report a homologous family of synthetic, chromophoric benzene phosphate substrates of SHIP2 that display the headgroup regio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acsmedchemlett.9b00368

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
ORCID:
0000-0003-3255-9135
et al.
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Medicinal Chemistry Letters Journal website
Volume:
11
Issue:
3
Pages:
309-315
Publication date:
2019-10-18
Acceptance date:
2019-10-18
DOI:
EISSN:
1948-5875
ISSN:
1948-5875
Source identifiers:
1063996
Language:
English
Keywords:
Pubs id:
pubs:1063996
UUID:
uuid:c6a0ecbf-fac1-48f2-845f-4b47876dbc5a
Local pid:
pubs:1063996
Deposit date:
2019-10-22

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