Journal article
Regioisomeric family of novel fluorescent substrates for SHIP2
- Abstract:
-
SHIP2 (SH2-domain containing inositol 5-phosphatase type 2) is a canonical 5-phosphatase, which, through its catalytic action on PtdInsP3, regulates the PI3K/Akt pathway and metabolic action of insulin. It is a drug target, but there is limited evidence of inhibition of SHIP2 by small molecules in the literature. With the goal to investigate inhibition, we report a homologous family of synthetic, chromophoric benzene phosphate substrates of SHIP2 that display the headgroup regio...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.7MB)
-
(Version of record, pdf, 1.2MB)
-
- Publisher copy:
- 10.1021/acsmedchemlett.9b00368
Authors
Funding
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- ACS Medicinal Chemistry Letters Journal website
- Volume:
- 11
- Issue:
- 3
- Pages:
- 309-315
- Publication date:
- 2019-10-18
- Acceptance date:
- 2019-10-18
- DOI:
- EISSN:
-
1948-5875
- ISSN:
-
1948-5875
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1063996
- UUID:
-
uuid:c6a0ecbf-fac1-48f2-845f-4b47876dbc5a
- Local pid:
- pubs:1063996
- Source identifiers:
-
1063996
- Deposit date:
- 2019-10-22
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2019
- Rights statement:
- Copyright © 2019 American Chemical Society. This is an open access article published under CC BY 4.0.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record