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A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies

Abstract:

Background

Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strongly selected mutations that are not associated with immune responses result in fitness losses.

Results

Strongly selected mutations were identified by analyzing 5′-half HIV-1 genome (gag/pol) sequences from longitudinal samples of su...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12977-017-0371-4

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Grant:
R01 OD011095
R01 AI028433
UM1 AI100645
U01 AI067854
U19 AI067854
R37 AI028433
Publisher:
BioMed Central Publisher's website
Journal:
Retrovirology Journal website
Volume:
14
Article number:
46
Publication date:
2017-10-10
Acceptance date:
2017-10-03
DOI:
EISSN:
1742-4690
ISSN:
1742-4690
Pmid:
29017536
Source identifiers:
737041
Language:
English
Keywords:
Pubs id:
pubs:737041
UUID:
uuid:c75e0b4b-e8fd-47c4-816e-b865af4e1f72
Local pid:
pubs:737041
Deposit date:
2018-01-25

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