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A human protein hydroxylase that accepts D-residues

Abstract:

Factor inhibiting hypoxia-inducible factor (FIH) is a 2-oxoglutarate-dependent protein hydroxylase that catalyses C3 hydroxylations of protein residues. We report FIH can accept (D)- and (L)-residues for hydroxylation. The substrate selectivity of FIH differs for (D) and (L) epimers, e.g., (D)- but not (L)-allylglycine, and conversely (L)- but not (D)-aspartate, undergo monohydroxylation, in the tested sequence context. The (L)-Leu-containing substrate undergoes FIH-catalysed monohydroxylatio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42004-020-0290-5

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Communications Chemistry Journal website
Volume:
3
Article number:
52
Publication date:
2020-05-01
Acceptance date:
2020-03-12
DOI:
EISSN:
2399-3669
Language:
English
Keywords:
Subjects:
Pubs id:
1102494
Local pid:
pubs:1102494
Deposit date:
2020-04-30

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