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Accessing complex genomic variation in Plasmodium falciparum natural infections

Abstract:

Genetic polymorphism in Plasmodium falciparum is a considerable obstacle to malaria intervention. Parasites have repeatedly evolved to overcome every front-line antimalarial deployed throughout history, and artemisinin resistant populations are expanding in Southeast Asia. Promising vaccine candidates routinely fail when challenged by the genetic diversity of natural parasite populations, and a recent trial using a blood-stage antigen showed immunity was allele specific. Mo...

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Institution:
University of Oxford
Research group:
Kwiatkowski group
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
Role:
Author

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Supervisor
Role:
Supervisor
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Funding agency for:
Jason Patrick Wendler
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:c9f1ea37-7005-4757-a869-7eba82406a26
Local pid:
ora:12264

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