Thesis
Accessing complex genomic variation in Plasmodium falciparum natural infections
- Abstract:
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Genetic polymorphism in Plasmodium falciparum is a considerable obstacle to malaria intervention. Parasites have repeatedly evolved to overcome every front-line antimalarial deployed throughout history, and artemisinin resistant populations are expanding in Southeast Asia. Promising vaccine candidates routinely fail when challenged by the genetic diversity of natural parasite populations, and a recent trial using a blood-stage antigen showed immunity was allele specific. Mo...
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Funding
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:c9f1ea37-7005-4757-a869-7eba82406a26
- Local pid:
- ora:12264
- Deposit date:
- 2015-09-24
Terms of use
- Copyright holder:
- Wendler, J
- Copyright date:
- 2015
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