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Journal article

Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent

Abstract:

Two important protein-protein interactions establish E-cadherin (Cdh1) in the adhesion complex; homophilic binding via the extra-cellular (EC1) domain and cytoplasmic tail binding to β-catenin. Here, we evaluate whether E-cadherin binding can inhibit β-catenin when there is loss of Adenomatous polyposis coli (APC) from the β-catenin destruction complex. Combined conditional loss of Cdh1 and Apc were generated in the intestine, intestinal adenoma and adenoma organoids. Combined intestinal disr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.11513

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Rhodes Trust More from this funder
Publisher:
Impact Journal Publisher's website
Journal:
Oncotarget Journal website
Volume:
7
Issue:
43
Pages:
69883-69902
Publication date:
2016-08-23
Acceptance date:
2016-08-08
DOI:
ISSN:
1949-2553
Pmid:
27566565
Source identifiers:
640863
Language:
English
Keywords:
Pubs id:
pubs:640863
UUID:
uuid:ca953b62-7592-4e09-b7f0-0cae0d0e55da
Local pid:
pubs:640863
Deposit date:
2016-10-05

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