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Thesis

Structural studies of integrin activation

Abstract:

Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that link the extracellular matrix to the actin cytoskeleton. Uniquely, these adhesion receptors mediate inside-out signal transduction, whereby extracellular adhesion is activated from within the cell by talin, a large cytoskeletal protein that binds to the cytoplasmic tail of the β integrin subunit via its PTB-like F3 domain. Features of the interface between talin1 and small β3 fragments only...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Lincoln College
Role:
Author
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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
More from this funder
Funding agency for:
Anthis, N
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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