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Journal article

Endoplasmic reticulum aminopeptidase 1 (ERAP1) plays a critical role in determining the length and sequence of peptides bound and presented by HLA-B27

Abstract:

Objective. HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). A key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation. We studied the effects of ERAP1 on the HLA-B27 peptide repertoire and peptide presentation to Cytotoxic T lymphocytes (CTLs).

Methods. ERAP1-silenced and -competent HeLa.B27/C1R.B27 cells were is...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.38249

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Southampton
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
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Funding agency for:
Reeves, E
Grant:
A10601
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Funding agency for:
Elliott, T
Grant:
A10601
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Funding agency for:
James, E
Grant:
A10601
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Publisher:
Wiley-Blackwell
Journal:
Arthritis and Rheumatism Journal website
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
Language:
English
Keywords:
Subjects:
UUID:
uuid:cb7e8621-7cb2-4c3a-b4bf-ac89ca9d7d6e
Local pid:
ora:7608
Deposit date:
2013-12-02

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