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Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis

Abstract:

BACKGROUND-: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic function. We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states. METHODS AND RESULTS-: In Study 1, 20 healthy individuals were randomized to receive Salmonella typhi vaccine (a model of acute inflammation) or placebo in a double-blind study. Vaccination increased circulating BH4 and i...

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Journal:
Circulation
Volume:
124
Issue:
17
Pages:
1860-1870
Publication date:
2011-10-25
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
206205
Language:
English
Keywords:
Pubs id:
pubs:206205
UUID:
uuid:cbd8e2d8-07c1-493c-b989-2bf633967589
Local pid:
pubs:206205
Deposit date:
2012-12-19

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