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Journal article

Mice deleted for Cell division cycle 73 gene develop parathyroid and uterine tumours: model for the Hyperparathyroidism-Jaw Tumour Syndrome

Abstract:

The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. To facilitate in vivo studies of Cdc73 in tumourigenesis we generated conventiona...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Institution:
University of Oxford
Oxford college:
Keble College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Grant:
G9825289/2004
G1000467/2010
Van Andel Foundation More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Oncogene Journal website
Publication date:
2017-03-13
Acceptance date:
2017-01-24
EISSN:
1476-5594
ISSN:
0950-9232
Source identifiers:
685816
Language:
English
Keywords:
Pubs id:
pubs:685816
UUID:
uuid:cc3f021b-6c35-46ec-a7ba-23530676f478
Local pid:
pubs:685816
Deposit date:
2017-03-15

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