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Thesis

KDM2B links recognition of CpG islands to polycomb domain formation in vivo

Abstract:

Mammalian genomes are characterised by global and pervasive DNA methylation and this modification is generally thought to be inhibitory to transcription. An exception to this widespread DNA modification are genomic elements called CpG islands (CGI), contiguous regions of non-methylated DNA which encompass the transcription start site of two thirds of mammalian genes. Although CGIs represent the most prominent feature of mammalian promoters, the contribution of these elements to promoter fu...

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Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Dr. Robert Klose
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
More from this funder
Funding agency for:
Farcas, A
Grant:
C28585/A10839
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:cc773afe-703c-4b43-a792-7ee7ba333bcd
Local pid:
ora:9808
Deposit date:
2015-01-27

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