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Thesis

Mathematical modelling of oncolytic virotherapy

Abstract:

This thesis is concerned with mathematical modelling of oncolytic virotherapy: the use of genetically modified viruses to selectively spread, replicate and destroy cancerous cells in solid tumours. Traditional spatially-dependent modelling approaches have previously assumed that virus spread is due to viral diffusion in solid tumours, and also neglect the time delay introduced by the lytic cycle for viral replication within host cells.

A deterministic, age-structured reaction-diffus...

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Research group:
Oxford Centre for Industrial and Applied Mathematics
Oxford college:
New College
Role:
Author

Contributors

Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
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Funding agency for:
Shabala, A
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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