Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
Carnitine is an essential metabolite in the human body. It carries out several roles in human metabolism, including that in fatty acid metabolism. γ-Butyrobetaine hydroxylase (BBOX) is an Fe(II) and 2-oxoglutarate dependent oxygenase, which catalyses the final step of carnitine biosynthesis, i.e. hydroxylation of γ-butyrobetaine (GBB) to carnitine. Inhibition of BBOX has potential in the treatment for cardiovascular diseases.
The work described in this thesis focussed on mechanisti...Expand abstract
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- Oxford University, UK
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- Anna Rydzik
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