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Phylogenetic analysis indicates that Evasin-like proteins of Ixodid ticks fall into three distinct classes

Abstract:

Chemokines are structurally related proteins that activate leucocyte migration in response to injury or infection. Tick saliva contains chemokine-binding proteins or evasins which likely neutralize host chemokine function and inflammation. Biochemical characterisation of 50 evasins from Ixodes, Amblyomma and Rhipicephalus shows that they fall into two functional classes, A and B, with exclusive binding to either CC- or CXC- chemokines, respectively. Class A evasins, EVA1 and EVA4 have a four-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fcimb.2021.769542

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Strategic
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-5571-0478
British Heart Foundation More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cellular and Infection Microbiology Journal website
Volume:
11
Article number:
769542
Publication date:
2021-10-22
Acceptance date:
2021-09-24
DOI:
EISSN:
2235-2988
Language:
English
Keywords:
Pubs id:
1203312
Local pid:
pubs:1203312
Deposit date:
2021-10-18

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