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iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction

Abstract:

The role of proinflammation, and specifically TNF-α, on downstream fibrosis and healing after cardiac injury remains unknown. Using iRhom2-deficient mice, which lack myeloid-specific shedding of TNF-α, we reveal increased macrophages (MΦs) that were skewed towards a more proinflammatory (M1) state at day 4, followed by more reparative, antiinflammatory (M2) state at day 7 after myocardial infarction (MI). However, associated functional cytokine expression was significantly reduced in iRhom2-m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.98268

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Grant:
RG/13/9/30269
CH/11/1/28798
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
3
Issue:
3
Article number:
e98268
Publication date:
2018-02-08
Acceptance date:
2017-12-29
DOI:
ISSN:
2379-3708
Language:
English
Keywords:
Pubs id:
pubs:823392
UUID:
uuid:cd233363-b43c-454a-96a4-c7a4ac917f46
Local pid:
pubs:823392
Deposit date:
2018-02-09

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