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Control of PTH secretion by the TRPC1 ion channel

Abstract:

Familial Hypocalciuric Hypercalcemia (FHH) is a genetic condition associated with hypocalciuria, hypercalcemia and in some cases inappropriately high levels of circulating parathyroid hormone (PTH). FHH is associated with inactivating mutations in CaSR encoding the Ca2+ sensing receptor (CaSR), a G protein coupled receptor (GPCR) and GNA11 encoding G protein subunit alpha 11 (Gα11), implicating defective GPCR signaling as the root pathophysiology for FHH. However, the downstream mechanism by ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.132496

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Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Contributor
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI insight Journal website
Volume:
5
Issue:
8
Article number:
e132496
Publication date:
2020-03-26
Acceptance date:
2020-03-16
DOI:
EISSN:
2379-3708
ISSN:
2379-3708
Pmid:
32213715
Language:
English
Keywords:
Pubs id:
1099239
Local pid:
pubs:1099239
Deposit date:
2020-04-15

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