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Thesis

Adapting nanobody scaffolds as protein chaperones for effective crystallization and good protein behaviour in cryo-EM

Abstract:

In the past three decades, structural biology has developed tremendously with the establishment of the X-ray crystallography and cryo-EM techniques. In order to satisfy the needs of those two techniques, methods have been developed to engineer the proteins of interest. One of the popular methods is binder-assisted structure solution. Among the various kinds of protein binders, nanobodies are one of the most frequently used tool in both X-ray crystallography and cryo-EM. Nanobodies are a sm...

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Division:
MSD
Department:
NDM
Sub department:
CM CMD
Research group:
Protein Crystallography SRF
Oxford college:
Worcester College
Role:
Author
ORCID:
0001-6324-4238

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CM CMD
Role:
Supervisor
Sub department:
CM CMD
Role:
Supervisor
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Programme:
China Scholarship Council - Nuffield Department of Medicine Scholarships
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-07-18

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