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The relationship between body mass index and the risk of development of Dupuytren's disease: a Mendelian randomization study.

Abstract:

We performed Mendelian randomization analyses of body mass index and waist-hip ratio adjusted for body mass index in Dupuytren's disease using summary statistics from genome-wide association study meta-analyses. We found that adiposity is causally protective against Dupuytren's disease, with the inverse-variance weighted Mendelian randomization analysis estimating that a 1 standard deviation increase in body mass index (equivalent to 4.8 kg/m2) leads to 28% (95% co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1753193420958553

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0003-4944-123X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0003-2780-7173
Department of Health More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
Journal of Hand Surgery (European Volume) Journal website
Volume:
46
Issue:
4
Pages:
406-410
Publication date:
2020-09-25
Acceptance date:
2020-08-24
DOI:
EISSN:
2043-6289
ISSN:
1753-1934
Pmid:
32972297
Language:
English
Keywords:
Pubs id:
1136059
Local pid:
pubs:1136059
Deposit date:
2021-12-09

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