Modulation of immune cell niches for therapeutics in cancer and inflammatory diseases

Thesis

Immune cell niches are microenvironments that support the survival of specific hematopoietic cells. The size of a given niche is dependent on survival and proliferation signals provided. Modulation of niche size can be a useful therapeutic tool, and a better understanding of the factors that control the size of immune cell niches can lead to more targeted therapies.

Here bone marrow and thymic niches were modulated with tyrosine kinase inhibition to achieve increased engraftment fo...

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Authors: Fewkes, N; Natasha Fewkes

• Publication date: 2012
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Hematopoietic Stem cell transplant; tolerance; Interleukin 7; niche; Dendritic cell; IL-7; Sunitinib; KIT
• Subjects: History of childhood; Immunology; Biology (medical sciences); Dendritic cell research; Medical Sciences