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Journal article

Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial.

Abstract:

Background

Lowering of LDL cholesterol reduces major vascular events, but whether more intensive therapy safely produces extra benefi ts is uncertain. We aimed to establish effi cacy and safety of more intensive statin treatment in patients at high cardiovascular risk.

Methods

We undertook a double-blind randomised trial in 12 064 men and women aged 18–80 years with a history of myocardial infarction. Participants were either currently on or had clear indication fo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s0140-6736(10)60310-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet (London, England) Journal website
Volume:
376
Issue:
9753
Pages:
1658-1669
Publication date:
2010-11-08
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
97244

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