NMR studies on 2-oxoglutarate oxygenases
The work described in this Thesis has focused on the application of nuclear magnetic resonance (NMR) spectroscopy to study the Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases, a family of structurally related enzymes that are ubiquitous in plants, micro-organisms and animals. The work included enzyme mechanistic studies, NMR method development, protein NMR and method development for inhibitor discovery.
NMR was applied to study human γ-butyrobetaine hydroxylase (BBOX), an enzym...Expand abstract
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- University of Oxford
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- Ivanhoe Leung
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