Thesis
NMR studies on 2-oxoglutarate oxygenases
- Abstract:
-
The work described in this Thesis has focused on the application of nuclear magnetic resonance (NMR) spectroscopy to study the Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases, a family of structurally related enzymes that are ubiquitous in plants, micro-organisms and animals. The work included enzyme mechanistic studies, NMR method development, protein NMR and method development for inhibitor discovery.
NMR was applied to study human γ-butyrobetaine hydroxylase (BBOX), an enzym...
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Authors
Contributors
+ Schofield, C
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
+ Claridge, T
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:ce13e7a1-7ec5-4d32-941f-35486827f868
- Deposit date:
- 2016-11-15
Terms of use
- Copyright holder:
- Ivanhoe Leung
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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