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Thesis

Multiscale molecular dynamics to investigate sodium ion channel oligomerisation

Abstract:

Electrical signalling is key to a vast number of biological processes within the nervous system. For this to occur, specific types of transmembrane proteins, named voltage-gated ion channels, are utilised. In voltage-gated sodium (Nav) channels, recent advances in structural biology are beginning to solve structures in complex with so-called “auxiliary” β subunits. These transmembrane proteins are multifunctional and interact with the main α subunit of the Nav channel, in addition to havin...

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Division:
MPLS
Department:
Chemistry
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-5100-8836
Role:
Supervisor
ORCID:
0000-0002-8991-1921
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Programme:
EPSRC Centre for Doctoral Training in Theory and Modelling in Chemical Sciences
Funding agency for:
Glass, WG
Grant:
EP/L015722/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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