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Thesis

HIV-specific interleukin-10 responses and immune modulation

Abstract:

Interleukin-10 (IL-10) helps to limit the duration of potentially harmful inflammatory responses but has also been implicated in the persistence of a number of chronic viral infections. This thesis aimed to investigate the phenotype and function of HIV-specific IL-10-producing cells in chronic HIV-1 infection, and the effect of IL-10 blockade on responses to candidate HIV-1 vaccines.

A cytokine capture assay was used to determine the HIV-specific cellular sources of IL- 10 in PBMC f...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Dorrell
Oxford college:
Merton College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:cf0ebf78-cdc0-4268-93b3-b6c8d72af6fb
Deposit date:
2016-11-15

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