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Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans.

Abstract:

Background.

The novel influenza vaccine MVA-NP+M1 is designed to boost cross-reactive T-cell responses to internal antigens of the influenza A virus that are conserved across all subtypes, providing protection against both influenza disease and virus shedding against all influenza A viruses. Following a phase 1 clinical study that demonstrated vaccine safety and immunogenicity, a phase 2a vaccination and influenza challenge study has been conducted in healthy ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cid/cis327

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More from this funder
Funding agency for:
Duncan, C
Grant:
081865
More from this funder
Funding agency for:
Hill, A
Gilbert, S
More from this funder
Funding agency for:
Berthoud, T
Lambe, T
Spencer, A
National Institute for Health Research More from this funder
Isis Innovation University Challenge Seed Fund More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Journal website
Volume:
55
Issue:
1
Pages:
19-25
Publication date:
2012-07-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Source identifiers:
320393

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