Journal article icon

Journal article

Structure of human Aichi virus and implications for receptor binding

Abstract:

Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and reaches 90% later in life3,4. There is no available vaccine or effective antiviral treatment. Here, we describe the structure of AiV at 3.7 Å. This first high-resolution structure...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/nmicrobiol.2016.150

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0003-4015-1404
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
ORCID:
0000-0002-4480-5439
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
ORCID:
0000-0002-0030-7235
Expand authors...
Biotechnology and Biological Sciences Research Council More from this funder
More from this funder
Funding agency for:
Ren, J
More from this funder
Funding agency for:
Fry, E
Grant:
G100099
More from this funder
Funding agency for:
Stuart, D
Grant:
G100099
Expand funders...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
1
Pages:
16150
Publication date:
2016-09-05
Acceptance date:
2016-07-21
DOI:
ISSN:
2058-5276
Pmid:
27595320
Source identifiers:
641710
Language:
English
Keywords:
Pubs id:
pubs:641710
UUID:
uuid:cff9ca7d-90b1-48de-a794-db2258ec066a
Local pid:
pubs:641710
Deposit date:
2018-09-03

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP