Investigating modifications to participant information materials to improve recruitment into a large randomized trial.
Background: Large randomized trials are the best method to test the efficacy and safety of treatments expected to have moderate effects. We observed a significant decline in potential participants’ response to mailed invitations to participate in such trials over a 10-year period and investigated possible reasons behind this and potential modifications to the invitation process to mitigate it.
Methods: Participants who declined to pa...Expand abstract
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