Journal article
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- Abstract:
-
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41588-017-0011-x
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 50
- Issue:
- 1
- Pages:
- 26-41
- Publication date:
- 2017-12-22
- Acceptance date:
- 2017-11-15
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Pmid:
-
29273807
- Source identifiers:
-
812802
Item Description
- Language:
- English
- Pubs id:
-
pubs:812802
- UUID:
-
uuid:d0395073-4628-410e-9038-b9ec85eeb757
- Local pid:
- pubs:812802
- Deposit date:
- 2018-01-24
Terms of use
- Copyright holder:
- Turcot et al
- Copyright date:
- 2017
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