Journal article
Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.
- Abstract:
-
Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiquitylation, which is triggered by DNA binding of proliferating cell nuclear antigen (PCNA). We show here that fission yeast Cdt1 interacts with PCNA in vivo and that DNA loading of PCNA is needed for Cdt1 proteolysis after DNA damage and in S phase. Activation of this pathway by ultraviolet (UV)-induced DNA damage requires upstream involvement of nucleoti...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Edward Penley Abraham Cephalosporin Fund
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Cancer Research UK
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic acids research Journal website
- Volume:
- 39
- Issue:
- 14
- Pages:
- 5978-5990
- Publication date:
- 2011-08-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:d0413a98-c98c-4592-b16b-68394f928ae4
- Local pid:
- pubs:209954
- Source identifiers:
-
209954
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Guarino et al
- Copyright date:
- 2011
- Notes:
- Copyright © 2011 Guarino et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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