Thesis
Oligonucleotide-based therapies for neuromuscular disease
- Abstract:
-
Genetic neuromuscular diseases remain essentially untreatable. Duchenne muscular dystrophy (DMD) is one such example and another is C9ORF72-related frontotemporal dementia/amyotrophic lateral sclerosis (c9FTD/ALS). Both these conditions may, however, be amenable to treatment with antisense oligonucleotide (ASO) compounds. Therapeutic ASO development for DMD is already in the clinical trial phase, while the applicability of ASO therapies in c9FTD/ALS remains to be clarified. No rel...
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Authors
Contributors
+ Wood, M
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Supervisor
+ Talbot, K
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:d14706a3-c436-46ff-87c4-40bbbad6dc01
- Local pid:
- ora:12156
- Deposit date:
- 2015-08-18
Terms of use
- Copyright holder:
- Andrew G L Douglas
- Copyright date:
- 2015
- Notes:
- This thesis is not currently available vis ORA.
- Licence:
- CC Attribution (CC BY)
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