Thesis
Targeting the hypoxic tumour phenotype with T-cell immunotherapy
- Abstract:
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The hypoxic tumour phenotype is a widespread phenomenon in cancers that correlates with malignant behaviour and poor clinical outcomes. The induced expression of hypoxia-regulated genes through post-translational stabilization of hypoxia-inducible factor (HIF), represent a novel class of over expressed tumour antigens that may bear relevance for specific T cell immunity. To assess whether hypoxia inducible proteins can elicit specific T cell responses in vivo, experiments were carried out ...
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Bibliographic Details
- Publication date:
- 2004
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Source identifiers:
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603828400
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:d22f1d74-44eb-4560-9249-f6127accd1b1
- Local pid:
- td:603828400
- Deposit date:
- 2013-01-21
Terms of use
- Copyright holder:
- Chong, T
- Copyright date:
- 2004
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
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