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Probing GPCR-Gα interactions: A functional study by EM and SPR

Abstract:

The G protein-coupled receptor (GPCR), neurotensin receptor type 1 (NTS1), is pharmacologically important and activated by the tridecapeptide hormone, neurotensin (NT), initiating a cascade of interactions through G proteins to effect cellular responses. The mechanisms by which these occur have only recently begun to be examined structurally, and standard assays involving downstream effectors or radioactive GTPγS G protein activation to describe GPCR-G protein interactions do not assay the...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Biomembrane Structure Unit
Oxford college:
Corpus Christi College
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Adamson, R
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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