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Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain

Abstract:
Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic analyses to localize individual genes acting pleiotropically upon these phenotypes. Methods: Whole-brain and regional GM thickness and FA value... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fnins.2011.00120

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Frontiers Media S.A. Publisher's website
Journal:
Frontiers in neuroscience Journal website
Volume:
5
Article number:
120
Publication date:
2011-10-19
DOI:
EISSN:
1662-4548
Source identifiers:
445993
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:445993
UUID:
uuid:d2670132-e3ad-483e-92a6-f7729e548225
Local pid:
pubs:445993
Deposit date:
2014-01-18

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