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Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

Abstract:

Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value of sugar and influences food preference, the neural circuitry that mediates the rewarding effect of glucose is unknown. In this study, we show that optogenetic activation of melanin-concentrating ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.01462

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Lady Margaret Hall
Role:
Author
ORCID:
0000-0002-7938-4814
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Role:
Author
ORCID:
0000-0001-9781-2221
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2
Pages:
01462
Publication date:
2013-12-31
Acceptance date:
2013-11-19
DOI:
EISSN:
2050-084X
Pmid:
24381247
Source identifiers:
864452
Language:
English
Keywords:
Pubs id:
pubs:864452
UUID:
uuid:d3de13aa-cea4-4395-b6b3-2a160eaffa1e
Local pid:
pubs:864452
Deposit date:
2018-08-09

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