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CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication

Abstract:

Background: Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention. Several recent T-cell vaccine trials showed no protection against HIV-1 acquisition although the vaccines induced HIV-1-specific T-cell responses, suggesting that the vaccine-induced T cells have insufficient capacities to suppress HIV-1 replication and/or cross-recognize circulating HIV-1. Therefore, it is necessary to develop...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12977-018-0429-y

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Publisher:
BioMed Central Publisher's website
Journal:
Retrovirology Journal website
Volume:
15
Publication date:
2018-07-03
Acceptance date:
2018-06-25
DOI:
EISSN:
1742-4690
Pmid:
29970102
Source identifiers:
869710
Language:
English
Keywords:
Pubs id:
pubs:869710
UUID:
uuid:d5a9efa7-06b7-4fd6-bf1e-f81b70a5f03a
Local pid:
pubs:869710
Deposit date:
2018-08-30

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